Drug Information

Drug General Information
Drug ID
D0VM2L
Former ID
DAP001023
Drug Name
Zoledronate
Synonyms
Aclasta; Reclast; ZOL; Zometa; Novartis brand of zoledronic acid; Zoledronic acid; Zometa Concentrate; Bisphosphonate 3; CGP 42446; CGP 42446A; Aclasta (TN); CGP 42'446; CGP-42446; KS-1132; Reclast (TN); Zoledronic acid (INN); Zoledronic acid [USAN:INN]; Zomera (TN); Zometa (Novartis); Zometa (TN); CGP-42'446; Zometa, Zomera, Aclasta and Reclast, Zoledronic Acid; [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid); (1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid; (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid; (1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid; (1-hydroxy-2-imidazol-1-yl-phosphonoethyl)phosphonic acid monohydrate; 2-(imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic acid; 2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid
Drug Type
Small molecular drug
Indication Hypercalcemia [ICD9: 275.42; ICD10:E83.5] Approved [536957]
Therapeutic Class
Bone Density Conservation Agents
Company
Norvatis Phamaceuticals Corporation
Structure
Download
2D MOL

3D MOL
Formula
C5H10N2O7P2
Canonical SMILES
C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O
InChI
1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
InChIKey
XRASPMIURGNCCH-UHFFFAOYSA-N
CAS Number
CAS 118072-93-8
PubChem Compound ID
68740
PubChem Substance ID
536160, 6436371, 7891233, 7980916, 8192311, 10318362, 10318375, 10318390, 10318944, 11528905, 14824151, 25819963, 29215499, 29215500, 43125267, 46507310, 46513035, 50473172, 53788750, 53801236, 56311814, 56436259, 56479320, 57317038, 81092860, 85174457, 87457600, 89736141, 92308965, 92712542, 93166450, 93167152, 96025372, 99343600, 99343604, 99437087, 99455519, 103240897, 104342928, 109692939, 117626547, 118048654, 124757161, 125163965, 125338822, 126592903, 126625470, 126656631, 126667014, 127324075
ChEBI ID
ChEBI:46557
SuperDrug ATC ID
M05BA08
SuperDrug CAS ID
cas=118072938
Target and Pathway
Target(s) Farnesyl pyrophosphate synthase Target Info Modulator [556264]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Trans, trans-farnesyl diphosphate biosynthesis
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Cholesterol biosynthesis
References
Ref 536957Current and future treatments of bone metastases. Expert Opin Emerg Drugs. 2008 Dec;13(4):609-27.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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