Drug Information

Drug General Information
Drug ID
D0VN2R
Former ID
DNC005602
Drug Name
6-(4-Hydroxy-phenyl)-1-phenyl-naphthalen-2-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527584]
Structure
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2D MOL

3D MOL
Formula
C22H16O2
Canonical SMILES
C1=CC=C(C=C1)C2=C(C=CC3=C2C=CC(=C3)C4=CC=C(C=C4)O)O
InChI
1S/C22H16O2/c23-19-10-6-15(7-11-19)17-8-12-20-18(14-17)9-13-21(24)22(20)16-4-2-1-3-5-16/h1-14,23-24H
InChIKey
INNGVLJQICTRAF-UHFFFAOYSA-N
PubChem Compound ID
10171886
Target and Pathway
Target(s) Estrogen receptor Target Info Inhibitor [527584]
Estrogen receptor beta Target Info Inhibitor [527584]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Proteoglycans in cancerhsa04915:Estrogen signaling pathway
NetPath Pathway FSH Signaling Pathway
EGFR1 Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
Plasma membrane estrogen receptor signaling
LKB1 signaling events
Regulation of Telomerase
ATF-2 transcription factor network
AP-1 transcription factor network
FOXM1 transcription factor network
Validated nuclear estrogen receptor alpha network
Signaling mediated by p38-alpha and p38-beta
FOXA1 transcription factor networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways Estrogen signaling pathway
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
Signaling by ERBB4
JAK/STAT
Integrated Pancreatic Cancer Pathway
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
Integrated Breast Cancer Pathway
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Ovarian Infertility Genes
Nuclear Receptors
References
Ref 527584J Med Chem. 2005 Jun 16;48(12):3953-79.ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity.
Ref 527584J Med Chem. 2005 Jun 16;48(12):3953-79.ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity.

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