Drug Information

Drug General Information
Drug ID
D0VO7R
Former ID
DNC000172
Drug Name
AjvW2
Drug Type
Antibody
Indication Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Phase 1 [546704]
Structure
Download
2D MOL

3D MOL
Formula
C12H18N4O4
Canonical SMILES
CC(C(C)N1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
InChI
1S/C12H18N4O4/c1-7(15-3-9(17)13-10(18)4-15)8(2)16-5-11(19)14-12(20)6-16/h7-8H,3-6H2,1-2H3,(H,13,17,18)(H,14,19,20)/t7-,8+
InChIKey
OBYGAPWKTPDTAS-OCAPTIKFSA-N
CAS Number
CAS 21416-88-6
PubChem Compound ID
119081
PubChem Substance ID
10238334, 11121749, 11122229, 11362901, 11365463, 11368025, 11370993, 11370994, 11373626, 11376187, 14750955, 24896062, 26756840, 26756841, 29300050, 48169020, 48393605, 50012867, 50111449, 57339319, 75114731, 92310100, 99301012, 99302532, 103567119, 104407504, 128786916, 134339682, 134340112, 135073849, 141868838, 162248102, 226761503, 241039874, 252455824
Target and Pathway
Target(s) Glycoprotein IIb/IIIa receptor Target Info [535352]
Reactome Platelet degranulation
Elastic fibre formation
PECAM1 interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
ECM proteoglycans
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
MAP2K and MAPK activation
WikiPathways Focal Adhesion
Hematopoietic Stem Cell Differentiation
Human Complement System
Extracellular matrix organization
Arrhythmogenic Right Ventricular Cardiomyopathy
Integrin-mediated Cell Adhesion
L1CAM interactions
Integrin cell surface interactions
Integrin alphaIIb beta3 signaling
References
Ref 546704Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009728)
Ref 535352Novel approaches to the treatment of thrombosis. Trends Pharmacol Sci. 2002 Jan;23(1):25-32.

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