Drug Information

Drug General Information
Drug ID
D0VU2X
Former ID
DAP000098
Drug Name
Conivaptan
Synonyms
Conivaptan [INN]; YM 087; YM087; Conivaptan (INN); Vaprisol (TN); YM-087; N-[4-(2-methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide; N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide; 4'-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilide
Drug Type
Small molecular drug
Indication Euvolemic hyponatremia [ICD9: 276.1; ICD10:E87.1] Approved [537060], [539403]
Company
Astellas Pharma Inc
Structure
Download
2D MOL

3D MOL
Formula
C32H26N4O2
InChI
InChI=1S/C32H26N4O2/c1-21-33-28-19-20-36(29-14-8-7-13-27(29)30(28)34-21)32(38)23-15-17-24(18-16-23)35-31(37)26-12-6-5-11-25(26)22-9-3-2-4-10-22/h2-18H,19-20H2,1H3,(H,33,34)(H,35,37)
InChIKey
IKENVDNFQMCRTR-UHFFFAOYSA-N
CAS Number
CAS 210101-16-9
PubChem Compound ID
151171
PubChem Substance ID
14933230, 46227736, 46504533, 46539970, 47285936, 47583799, 50070653, 50300910, 57347309, 85209766, 85210128, 93608331, 96024467, 99299517, 103707723, 104154132, 104430350, 125824483, 128179844, 134337425, 134338921, 134340688, 134340689, 135106955, 135651340, 136351195, 137005849, 137263556, 138069836, 140034093, 142385717, 152057312, 160964213, 172085102, 174006907, 175266283, 179225632, 179293751, 184528844, 196109797, 223957134, 226433457, 244302846, 251971383, 252215185
SuperDrug ATC ID
C03XA02
Target and Pathway
Target(s) Vasopressin V2 receptor Target Info Modulator [526189], [529082]
Vasopressin V1a receptor Target Info Modulator [526189], [529082]
KEGG Pathway Neuroactive ligand-receptor interaction
Vasopressin-regulated water reabsorptionhsa04020:Calcium signaling pathway
Vascular smooth muscle contraction
Pathway Interaction Database Arf6 trafficking events
PathWhiz Pathway Vasopressin Regulation of Water Homeostasis
Reactome Vasopressin-like receptors
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via AquaporinsR-HSA-388479:Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Regulation of Water Balance by Renal Aquaporins
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 537060Emerging diuretics for the treatment of heart failure. Expert Opin Emerg Drugs. 2009 Mar;14(1):195-204.
Ref 539403(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2203).
Ref 526189Acute hemodynamic effects of conivaptan, a dual V(1A) and V(2) vasopressin receptor antagonist, in patients with advanced heart failure. Circulation. 2001 Nov 13;104(20):2417-23.
Ref 529082Conivaptan: a dual vasopressin receptor v1a/v2 antagonist [corrected]. Cardiovasc Drug Rev. 2007 Fall;25(3):261-79.

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