Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0VU7U
|
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| Former ID |
DCL000606
|
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| Drug Name |
R3487
|
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| Drug Type |
Small molecular drug
|
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| Indication | Alzheimer disease; Schizophrenia [ICD9: 295, 331.0; ICD10:F20, G30] | Phase 2 | [1] | ||
| Company |
Roche
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
Na
|
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| Canonical SMILES |
[Na]
|
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| InChI |
1S/Na
|
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| InChIKey |
KEAYESYHFKHZAL-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
5326610, 8146756, 10534514, 15170295, 15237733, 24845275, 24848128, 24853383, 24854694, 24855921, 24857014, 24857016, 24868737, 24871915, 24881721, 24886151, 24886235, 24888697, 33088985, 39384005, 50046431, 50074094, 53788965, 57362018, 57647078, 57648086, 57652275, 57652326, 77905220, 83620210, 88826695, 114148349, 117376386, 125809647, 126675963, 131325865, 134339053, 134339153, 134339154, 134339155, 134339359, 134339385, 134339536, 134339884, 134340144, 134987874, 134988506, 137102243, 137156482, 139072878
|
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| Target and Pathway | |||||
| Target(s) | Neuronal acetylcholine receptor protein, alpha-7 chain | Target Info | Agonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Cholinergic synapse | |||||
| Nicotine addiction | |||||
| Chemical carcinogenesis | |||||
| PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
| Nicotinic acetylcholine receptor signaling pathway | |||||
| Reactome | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| References | |||||
| REF 1 | Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nat Rev Drug Discov. 2009 Sep;8(9):733-50. | ||||
| REF 2 | Clinical pipeline report, company report or official report of Roche (2009). | ||||
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