TTD | Drug: D0W3GL

Drug General Information
Drug ID	D0W3GL
Former ID	DNC005420
Drug Name	SR-147778
Drug Type	Small molecular drug
Indication	Obesity [ICD9: 278; ICD10:E66]		Phase 2	[521745]
Structure		Download 2D MOL 3D MOL
Formula	C23H23BrCl2N4O
Canonical SMILES	CCC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C<br />(C=C4)Br
InChI	1S/C23H23BrCl2N4O/c1-2-18-21(23(31)28-29-12-4-3-5-13-29)27-30(20-11-10-17(25)14-19(20)26)22(18)15-6-8-16(24)9-7-15/h6-11,14H,2-5,12-13H2,1H3,(H,28,31)
InChIKey	HMXDWDSNPRNUKI-UHFFFAOYSA-N
PubChem Compound ID	9849616
Target and Pathway
Target(s)	Cannabinoid receptor 1	Target Info	Modulator
KEGG Pathway	Rap1 signaling pathway
	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
PANTHER Pathway	Endogenous cannabinoid signaling
Pathway Interaction Database	N-cadherin signaling events
Reactome	Class A/1 (Rhodopsin-like receptors)
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	BDNF signaling pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 521745	ClinicalTrials.gov (NCT00239174) A Multicenter Study to Evaluate the Efficacy and Safety of of Four Doses of SR147778 in Obese Patients. U.S. National Institutes of Health.

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Drug Information