Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0W3RR
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| Former ID |
DNC004365
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| Drug Name |
2-Morpholin-4-yl-8-phenylethynyl-chromen-4-one
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| Synonyms |
2-morpholino-8-(2-phenylethynyl)-4H-chromen-4-one
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| Indication | Discovery agent | Investigative | [527870] | ||
| Structure |
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Download2D MOL |
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| Canonical SMILES |
C1COCCN1C2=CC(=O)C3=CC=CC(=C3O2)C#CC4=CC=CC=C4
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| InChI |
1S/C21H17NO3/c23-19-15-20(22-11-13-24-14-12-22)25-21-17(7-4-8-18(19)21)10-9-16-5-2-1-3-6-16/h1-8,15H,11-14H2
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| InChIKey |
FVCZHPDXMMYSDW-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | CGMP-inhibited 3',5'-cyclic phosphodiesterase A | Target Info | Inhibitor | [527870] | |
| CGMP-dependent3',5'-cyclic phosphodiesterase | Target Info | Inhibitor | [527068] | ||
| NetPath Pathway | TSH Signaling Pathway | ||||
| References | |||||
| Ref 527068 | Bioorg Med Chem Lett. 2004 Jun 7;14(11):2847-51.PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues. | ||||
| Ref 527870 | Bioorg Med Chem Lett. 2006 Feb 15;16(4):969-73. Epub 2005 Nov 15.Analysis of anti-PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity. | ||||
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