Drug General Information
Drug ID	D0W4UX
Drug Name	BMS-187308
Synonyms	153624-15-8; BMS-187308
Drug Type	Small molecular drug
Indication	Unspecified		Investigative	[1560225]
Structure		Download 2D MOL 3D MOL
Formula	C21H25N3O3S
PubChem Compound ID	9908909
Target and Pathway
Target(s)	Endothelin-1 receptor	Target Info	Modulator
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Renin secretion
	Pathways in cancer
NetPath Pathway	IL4 Signaling Pathway
PANTHER Pathway	Endothelin signaling pathway
Pathway Interaction Database	Endothelins
	EGFR-dependent Endothelin signaling events
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 1560225	Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308).

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