Drug General Information
Drug ID
D0W4WP
Former ID
DIB011295
Drug Name
CVT-10216
Synonyms
CVT-10083; CVT-10200; CVT-10992; ALDH2 antagonists (alcoholism), CV Therapeutics; ALDH2 antagonists (alcoholism), Gilead Palo Alto; Aldehyde dehydrogenase-2 antagonists (alcoholism), CV Therapeutics
Drug Type
Small molecular drug
Indication Alcohol use disorders [ICD9: 303; ICD10:F10.2] Investigative [543653]
Company
Gilead Palo Alto Inc
Structure
Download
2D MOL

3D MOL

Formula
C24H19NO7S
Canonical SMILES
O=S(=O)(Nc1ccc(c2coc3c(c2=O)ccc(c3)OCc2cccc(c2)C(=O)O)c<br />c1)C
PubChem Compound ID
Target and Pathway
Target(s) Aldehyde dehydrogenase, mitochondrial Target Info Antagonist [543653]
KEGG Pathway Glycolysis / Gluconeogenesis
Pentose and glucuronate interconversions
Ascorbate and aldarate metabolism
Fatty acid degradation
Valine, leucine and isoleucine degradation
Lysine degradation
Arginine and proline metabolism
Histidine metabolism
Tryptophan metabolism
beta-Alanine metabolism
Glycerolipid metabolism
Pyruvate metabolism
Metabolic pathways
Biosynthesis of antibiotics
PathWhiz Pathway Beta-Alanine Metabolism
Ethanol Degradation
Histidine Metabolism
Valine, Leucine and Isoleucine Degradation
Pyruvate Metabolism
Oxidation of Branched Chain Fatty Acids
Glycine and Serine Metabolism
Tryptophan Metabolism
WikiPathways Tryptophan metabolism
Fatty Acid Omega Oxidation
Phase 1 - Functionalization of compounds
Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 543653(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2595).
Ref 543653(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2595).

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