Drug Information

Drug General Information
Drug ID
D0W6DY
Former ID
DAP001071
Drug Name
Diphenylpyraline
Synonyms
Allergen; Belfene; Dafen; Dayfen; Diafen; Difenilpiralina; Diphenylpyralamine; Diphenylpyralinum; Diphenylpyrilene; Hispril; Histryl; Histyn; Hystryl; Lergobine; Lyssipoll; Mepiben; Neargal; AN 1041; Difenilpiralina [INN-Spanish]; Diphenylpyraline (INN); Diphenylpyraline [INN:BAN]; Diphenylpyralinum [INN-Latin];Diphenylpyraline maleate (2:1); N-Methylpiperidyl-(4)-benzhydrylaether salzsauren salze; N-Methylpiperidyl-(4)-benzhydrylaether salzsauren salze [German]; 1-Methyl-4-piperidyl benzhydryl ether; 1-methyl-4-hydroxypiperidine benzhydryl ether; 4-(Benzhydryloxy)-1-methylpiperidine; 4-(Diphenylmethoxy)-1-methylpiperidine; 4-(benzhydryloxy)-N-methylpiperidine; 4-DIPHENYLMETHOXY-1-METHYLPIPERIDINE; 4-[(diphenylmethyl)oxy]-1-methylpiperidine; 4-benzhydryloxy-1-methylpiperidine
Drug Type
Small molecular drug
Indication Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] Approved [542174], [550716]
Therapeutic Class
Antihistamines
Structure
Download
2D MOL

3D MOL
Formula
C19H23NO
InChI
InChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3
InChIKey
OWQUZNMMYNAXSL-UHFFFAOYSA-N
CAS Number
CAS 147-20-6
PubChem Compound ID
3103
PubChem Substance ID
615228, 5046068, 8151975, 10508417, 11112289, 11336026, 11361265, 11363896, 11366458, 11369020, 11371242, 11374260, 11377182, 11455164, 11462237, 11466735, 11467855, 11484779, 11486550, 11488798, 11490217, 11492336, 11494816, 15442665, 29222246, 46504936, 47365245, 47365246, 47515368, 47736537, 47885465, 48185045, 48259283, 48334549, 48415912, 49698858, 50016255, 50123603, 50123604, 50938711, 57321610, 85171690, 85209863, 85788475, 92729772, 96024558, 99319623, 103555994, 103856536, 104098725
SuperDrug ATC ID
R06AA07
SuperDrug CAS ID
cas=000147206
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [537891]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 542174(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7165).
Ref 550716Drug information of Diphenylpyraline, 2008. eduDrugs.
Ref 537891Transport mechanism of an H1-antagonist at the blood-brain barrier: transport mechanism of mepyramine using the carotid injection technique. Biol Pharm Bull. 1994 May;17(5):676-9.

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