Drug Information

Drug General Information
Drug ID
D0W6JO
Former ID
DNC007532
Drug Name
QUISQUALATE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538850]
Structure
Download
2D MOL
Formula
C5H7N3O5
InChI
InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
InChIKey
ASNFTDCKZKHJSW-REOHCLBHSA-N
PubChem Compound ID
40539
PubChem Substance ID
10494, 829151, 3153217, 7890168, 7980474, 8176644, 11113399, 14867669, 17405597, 17436194, 24278004, 24770702, 26751639, 34706304, 46392526, 46392527, 46392847, 46509075, 46517821, 47170012, 47193871, 47589201, 47736719, 48110694, 50064863, 50104331, 50104332, 53786831, 57312446, 79846616, 85164420, 90341112, 91702071, 92303337, 103195075, 104050226, 104334657, 117593873, 118696079, 121362063, 124750188, 124800475, 127453052, 134344737, 135004298, 135650876, 135651194, 135676646, 135685944, 135697895
Target and Pathway
Target(s) Glutamate receptor, ionotropic kainate 1 Target Info Inhibitor [529560]
Metabotropicglutamate receptor 1 Target Info Inhibitor [534590]
Metabotropic glutamate receptor Target Info Inhibitor [534590]
Metabotropic glutamate receptor 7 Target Info Inhibitor [534590]
Metabotropic glutamate receptor 2 Target Info Inhibitor [534590]
Metabotropic glutamate receptor3 Target Info Inhibitor [534590]
Metabotropic glutamate receptor 8 Target Info Inhibitor [534590]
Metabotropic glutamate receptor 5 Target Info Inhibitor [534590]
Glutamate carboxypeptidase II Target Info Inhibitor [528891]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapsehsa04020:Calcium signaling pathway
FoxO signaling pathway
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathwayhsa04080:Neuroactive ligand-receptor interaction
Glutamatergic synapsehsa04080:Neuroactive ligand-receptor interaction
Cocaine addictionhsa04080:Neuroactive ligand-receptor interaction
Huntington's diseasehsa00250:Alanine, aspartate and glutamate metabolism
Metabolic pathways
Vitamin digestion and absorption
NetPath Pathway TCR Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signalingP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group III pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-416476:G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-70614:Amino acid synthesis and interconversion (transamination)
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP666:Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
GPCR downstream signalingWP241:One Carbon Metabolism
References
Ref 538850(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1372).
Ref 528891J Med Chem. 2007 Jul 12;50(14):3267-73. Epub 2007 Jun 14.Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.
Ref 529560J Med Chem. 2008 Jul 24;51(14):4093-103. Epub 2008 Jun 25.Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation ofionotropic glutamate receptor subtypes 5, 6, and 7.
Ref 534590J Med Chem. 1998 Mar 12;41(6):930-9.Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.

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