Drug Information

Drug General Information
Drug ID
D0W6XL
Former ID
DIB000323
Drug Name
SB-209670
Synonyms
SKF-66861; (+/-)-SB 209670
Drug Type
Small molecular drug
Indication Arrhythmia [ICD9: 427; ICD10:I47-I49] Discontinued in Phase 2 [540461], [545631]
Company
SmithKline Beecham plc
Structure
Download
2D MOL

3D MOL
Formula
C29H28O9
InChI
InChI=1S/C29H28O9/c1-3-10-35-18-6-7-19-21(12-18)27(20-8-5-17(34-2)13-23(20)36-14-25(30)31)28(29(32)33)26(19)16-4-9-22-24(11-16)38-15-37-22/h4-9,11-13,26-28H,3,10,14-15H2,1-2H3,(H,30,31)(H,32,33)/t26-,27+,28+/m0/s1
InChIKey
UUAVCCWBNUITBB-UPRLRBBYSA-N
PubChem Compound ID
108002
PubChem Substance ID
7980567, 10234546, 14860653, 44436915, 47660052, 49982656, 53787918, 57338378, 76054936, 103168074, 103973307, 104380252, 129420625, 135066706, 142093996, 178100507, 198936705, 227280102
Target and Pathway
Target(s) Endothelin-1 receptor Target Info Modulator [534175]
Endothelin B receptor Target Info Modulator [534175]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Renin secretion
Pathways in cancerhsa04020:Calcium signaling pathway
Melanogenesis
Pathways in cancer
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Endothelin signaling pathwayP00019:Endothelin signaling pathway
Pathway Interaction Database Endothelins
EGFR-dependent Endothelin signaling eventsendothelinpathway:Endothelins
Arf6 trafficking events
Reactome Peptide ligand-binding receptors
G alpha (q) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP98:Prostaglandin Synthesis and Regulation
References
Ref 540461(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3528).
Ref 545631Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003996)
Ref 534175Effects of the endothelin receptor antagonist, SB 209670, on circulatory failure and organ injury in endotoxic shock in the anaesthetized rat. Br J Pharmacol. 1996 May;118(1):198-204.

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