Drug General Information
Drug ID	D0W7GH
Former ID	DIB006773
Drug Name	IC-747
Synonyms	LFA-1 antagonists, ICOS/Biogen
Indication	Psoriasis [ICD9: 696; ICD10:L40]		Discontinued in Phase 2	[547348]
Company	ICOS Corp
Structure		Download 2D MOL 3D MOL
Canonical SMILES	S(c1c(cc(cc1)Cl)Cl)c1c(cc(N)cc1)Cl.Cl
CAS Number	CAS 300808-34-8
Target and Pathway
Target(s)	Lymphocyte function-associated antigen 1	Target Info	Antagonist	[551183]
KEGG Pathway	Rap1 signaling pathway
	Cell adhesion molecules (CAMs)
	Natural killer cell mediated cytotoxicity
	Leukocyte transendothelial migration
	Regulation of actin cytoskeleton
	Malaria
	Staphylococcus aureus infection
	HTLV-I infection
	Epstein-Barr virus infection
	Rheumatoid arthritis
	Viral myocarditis
NetPath Pathway	TCR Signaling Pathway
	RANKL Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
	Integrin signalling pathway
Pathway Interaction Database	Integrin family cell surface interactions
	Beta2 integrin cell surface interactions
	CXCR3-mediated signaling events
Reactome	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Cell surface interactions at the vascular wall
	Integrin cell surface interactions
WikiPathways	Focal Adhesion
	Integrin-mediated Cell Adhesion
	Integrin cell surface interactions
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Cell surface interactions at the vascular wall
References
Ref 547348	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015378)
Ref 551183	HECA-452+ T Cells Migrate Through Superficial Vascular Plexus but Not Through Deep Vascular Plexus Endothelium. Journal of Investigative Dermatology. 04/1997; 108(3):343-8.

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