Drug Information

Drug General Information
Drug ID
D0W7JF
Former ID
DNC013010
Drug Name
6-cyano-7-nitroquinoxaline-2,3-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540876]
Formula
C9H4N4O4
InChI
InChI=1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
InChIKey
RPXVIAFEQBNEAX-UHFFFAOYSA-N
PubChem Compound ID
3721046
PubChem Substance ID
586261, 3153197, 6755090, 7978981, 9848633, 11113401, 14749366, 14798224, 15366159, 16959940, 24892392, 26751641, 41107183, 47216988, 47515531, 48110666, 49738150, 50064192, 50620523, 53790056, 57356507, 84943270, 85085024, 85787585, 85787788, 88813857, 89651136, 95515025, 103509728, 104084998, 109614636, 112157853, 118507699, 125388318, 129164847, 135016987, 137045682, 139216164, 140361328, 141003657, 143551540, 162022475, 162079659, 166732091, 178100904, 178102124, 179293798, 184580095, 198982161, 216088070
Target and Pathway
Target(s) Glutamate receptor AMPA subtype Target Info Inhibitor [528135]
Glutamate receptor 1 Target Info Inhibitor [528135]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Dopaminergic synapse
Long-term depression
Amyotrophic lateral sclerosis (ALS)
Amphetamine addiction
Nicotine addiction
PANTHER Pathway Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Pathway Interaction Database EPHB forward signaling
Reactome COPII (Coat Protein 2) Mediated Vesicle Transport
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
Cargo concentration in the ER
WikiPathways Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Amyotrophic lateral sclerosis (ALS)
BDNF signaling pathway
References
Ref 540876(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5475).
Ref 528135J Med Chem. 2006 Apr 20;49(8):2579-92.Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists.

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