Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0W7VG
|
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| Former ID |
DCL000423
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| Drug Name |
AMG 108
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| Drug Type |
Small molecular drug
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| Indication | Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] | Discontinued in Phase 2 | [547930] | ||
| Company |
Amgen
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| Structure |
|
Download2D MOL |
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| Formula |
C11H14N4O4
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| Canonical SMILES |
C1=C(C2=C(N1)C(=O)N=CN2)C3C(C(C(N3)CO)O)O
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| InChI |
1S/C11H14N4O4/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19)/t5-,7+,9-,10+/m1/s1
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| InChIKey |
IWKXDMQDITUYRK-KUBHLMPHSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
820339, 824927, 829471, 854455, 854458, 7888374, 11532495, 14774821, 15392822, 24770619, 24770621, 24770665, 36887500, 46391523, 46391948, 46392657, 46394112, 46394113, 46530883, 47208247, 49689710, 57404625, 77434485, 85856193, 103500429, 104077585, 104632275, 117682608, 134338803, 134339052, 134340118, 135020342, 135675084, 137042995, 141755560, 144080329, 160644592, 160779316, 165245606, 180372225, 186024301, 198952847, 224718993, 226820362, 241051921, 243906436, 252166484
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| ChEBI ID |
ChEBI:43362
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| Target and Pathway | |||||
| Target(s) | Interleukin-1 receptor, type II | Target Info | Antagonist | [536524], [550250] | |
| NetPath Pathway | IL1 Signaling Pathway | ||||
| TNFalpha Signaling Pathway | |||||
| Pathway Interaction Database | IL1-mediated signaling events | ||||
| Reactome | Interleukin-1 signaling | ||||
| References | |||||
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