| Drug General Information |
| Drug ID |
D0WD6J
|
| Former ID |
DNC003878
|
| Drug Name |
1-Benzyl-4-(2-oxazol-5-yl-pyrrol-1-yl)-piperidine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C19H21N3O
|
| Canonical SMILES |
C1CN(CCC1N2C=CC=C2C3=CN=CO3)CC4=CC=CC=C4
|
| InChI |
1S/C19H21N3O/c1-2-5-16(6-3-1)14-21-11-8-17(9-12-21)22-10-4-7-18(22)19-13-20-15-23-19/h1-7,10,13,15,17H,8-9,11-12,14H2
|
| InChIKey |
JTHXHSNJAJMWTQ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Dopamine D1 receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
| D(4) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
| D(3) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Calcium signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Gap junction
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Dopaminergic synapse
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Parkinson's disease
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Cocaine addiction
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Amphetamine addiction
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Morphine addiction
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Alcoholismhsa04015:Rap1 signaling pathway
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Alcoholismhsa04080:Neuroactive ligand-receptor interaction
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Dopaminergic synapsehsa04080:Neuroactive ligand-receptor interaction
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PANTHER Pathway
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Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Nicotine pharmacodynamics pathway
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PathWhiz Pathway
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Dopamine Activation of Neurological Reward System
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Reactome
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Dopamine receptors
|
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G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling events
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WikiPathways
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Hypothetical Network for Drug Addiction
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Genes and (Common) Pathways Underlying Drug Addiction
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GPCR ligand binding
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GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
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Nicotine Activity on Dopaminergic Neurons
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GPCRs, OtherWP58:Monoamine GPCRs
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GPCRs, Other
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| References |
| REF 1 | Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6.Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. |
|---|
