Drug Information

Drug General Information
Drug ID
D0WD6K
Former ID
DIB007179
Drug Name
VPM-4-001
Synonyms
Allogenic LNCaP cell vaccine (prostate tumor), Vakzine Projekt Management; Cell vaccine (prostate cancer), Vakzine Projekt Management; Allogenic LNCaP cells (IL-2, IFN-gamma), Vakzine Projekt Management
Drug Type
Vaccine
Indication Prostate cancer [ICD9: 185; ICD10:C61] Preclinical [548240]
Company
Memorial Sloan-Kettering Cancer Center
Target and Pathway
Target(s) Interleukin-2 Target Info [530762]
Interferon gamma Target Info [530762]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
T cell receptor signaling pathway
Intestinal immune network for IgA production
Type I diabetes mellitus
Chagas disease (American trypanosomiasis)
Measles
HTLV-I infection
Autoimmune thyroid disease
Inflammatory bowel disease (IBD)
Allograft rejection
Graft-versus-host diseasehsa03050:Proteasome
HIF-1 signaling pathway
Regulation of autophagy
TGF-beta signaling pathway
Osteoclast differentiation
Antigen processing and presentation
Natural killer cell mediated cytotoxicity
Salmonella infection
Leishmaniasis
African trypanosomiasis
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Influenza A
Herpes simplex infection
Epstein-Barr virus infection
Systemic lupus erythematosus
Rheumatoid arthritis
Graft-versus-host disease
NetPath Pathway IL-7 Signaling Pathway
TCR Signaling Pathway
TNFalpha Signaling PathwayNetPath_13:IL1 Signaling Pathway
IL2 Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
Interferon-gamma signaling pathway
Pathway Interaction Database IL27-mediated signaling events
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
SHP2 signaling
Regulation of Telomerase
Glucocorticoid receptor regulatory network
IL2-mediated signaling events
IL2 signaling events mediated by PI3K
AP-1 transcription factor network
IL23-mediated signaling events
IL2 signaling events mediated by STAT5
Calcium signaling in the CD4+ TCR pathway
Downstream signaling in na&#xef
IL12 signaling mediated by STAT4il27pathway:IL27-mediated signaling events
IFN-gamma pathway
ATF-2 transcription factor network
PDGFR-alpha signaling pathway
IL12 signaling mediated by STAT4
Reactome GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-2 signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signalingR-HSA-877300:Interferon gamma signaling
Regulation of IFNG signaling
WikiPathways Cytokines and Inflammatory Response
IL-2 Signaling Pathway
Inflammatory Response Pathway
Aryl Hydrocarbon Receptor Pathway
Interleukin-2 signaling
T-Cell Receptor and Co-stimulatory Signaling
Spinal Cord Injury
Corticotropin-releasing hormone
Allograft Rejection
Arylhydrocarbon receptor (AhR) signaling pathway
Interleukin-3, 5 and GM-CSF signaling
Folate Metabolism
IL-5 Signaling PathwayWP619:Type II interferon signaling (IFNG)
Senescence and Autophagy in Cancer
TGF Beta Signaling Pathway
Hypertrophy Model
IL1 and megakaryotyces in obesity
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Interferon gamma signaling
Proteasome Degradation
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 548240Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023655)
Ref 530762BioPartnering North America--Programs from Pharma in Europe and the Middle East. IDrugs. 2010 Mar;13(3):162-5.

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