Drug General Information
Drug ID	D0WN9P
Former ID	DNC011035
Drug Name	4'-(Pyridin-4-ylmethyl)biphenyl-3-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531085]
Structure		Download 2D MOL 3D MOL
Formula	C18H16N2
Canonical SMILES	C1=CC(=CC(=C1)N)C2=CC=C(C=C2)CC3=CC=NC=C3
InChI	1S/C18H16N2/c19-18-3-1-2-17(13-18)16-6-4-14(5-7-16)12-15-8-10-20-11-9-15/h1-11,13H,12,19H2
InChIKey	MVDKLMQNQSJYHJ-UHFFFAOYSA-N
PubChem Compound ID	46901444
Target and Pathway
Target(s)	Cytochrome P450 19	Target Info	Inhibitor	[531085]
	17 alpha-hydroxylase-C17, 20-lyase	Target Info	Inhibitor	[531085]
	Cytochrome P450 11B1, mitochondrial	Target Info	Inhibitor	[531085]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Estradiol biosynthesis II
	Estradiol biosynthesis IPWY-7305:Superpathway of steroid hormone biosynthesis
	Glucocorticoid biosynthesis
	Androgen biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
	Mineralocorticoid biosynthesis
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathways
	Ovarian steroidogenesishsa00140:Steroid hormone biosynthesis
	Ovarian steroidogenesis
	Prolactin signaling pathwayhsa00140:Steroid hormone biosynthesis
NetPath Pathway	FSH Signaling Pathway
PANTHER Pathway	Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway	Androgen and Estrogen MetabolismPW000045:Androgen and Estrogen Metabolism
	SteroidogenesisPW000141:Steroidogenesis
Reactome	Endogenous sterolsR-HSA-193048:Androgen biosynthesis
	Glucocorticoid biosynthesis
	Endogenous sterolsR-HSA-194002:Glucocorticoid biosynthesis
	Endogenous sterols
WikiPathways	Metapathway biotransformation
	Tryptophan metabolism
	Oxidation by Cytochrome P450
	Ovarian Infertility Genes
	Metabolism of steroid hormones and vitamin D
	FSH signaling pathway
	Integrated Breast Cancer Pathway
	Phase 1 - Functionalization of compoundsWP702:Metapathway biotransformation
	Steroid Biosynthesis
	Glucocorticoid & Mineralcorticoid Metabolism
	Prostate Cancer
	Corticotropin-releasing hormone
References
Ref 531085	J Med Chem. 2010 Aug 12;53(15):5749-58.Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.
Ref 531085	J Med Chem. 2010 Aug 12;53(15):5749-58.Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.

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