Drug Information

Drug General Information
Drug ID
D0WO3A
Former ID
DIB020341
Drug Name
methylfurmethide
Synonyms
5-methylfurmithide; 5 MFT
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540010]
Structure
Download
2D MOL
Formula
C9H16NO+
InChI
InChI=1S/C9H16NO/c1-8-5-6-9(11-8)7-10(2,3)4/h5-6H,7H2,1-4H3/q+1
InChIKey
KOWVJDFMEZKDDT-UHFFFAOYSA-N
PubChem Compound ID
4141
PubChem Substance ID
1095591, 5327539, 8152596, 11113582, 25635103, 26756580, 29223248, 50070264, 50070936, 57322163, 75458597, 85209173, 85787559, 103299682, 103835059, 103921295, 104305548, 117602837, 126407803, 128413664, 135077123, 135650592, 139986483, 144087396, 165374517, 223466299, 235565732
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M3 Target Info Agonist [534426]
Muscarinic receptor Target Info Agonist [534426]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretionhsa04020:Calcium signaling pathway
cAMP signaling pathway
PI3K-Akt signaling pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Gastric Acid ProductionPW000564:Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Secretion of Hydrochloric Acid in Parietal Cells
References
Ref 540010(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 300).
Ref 534426Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9.

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