Drug Information

Drug General Information
Drug ID
D0WO8A
Former ID
DNC006100
Drug Name
1,3,5-tris(4-chlorophenyl)imidazolidine-2,4-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527995]
Structure
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2D MOL

3D MOL
Formula
C21H13Cl3N2O2
Canonical SMILES
C1=CC(=CC=C1C2C(=O)N(C(=O)N2C3=CC=C(C=C3)Cl)C4=CC=C(C=C<br />4)Cl)Cl
InChI
1S/C21H13Cl3N2O2/c22-14-3-1-13(2-4-14)19-20(27)26(18-11-7-16(24)8-12-18)21(28)25(19)17-9-5-15(23)6-10-17/h1-12,19H
InChIKey
CUKPDQSSXDAABM-UHFFFAOYSA-N
PubChem Compound ID
11690547
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Inhibitor [527995]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 527995J Med Chem. 2006 Feb 9;49(3):872-82.Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cannabinoid receptorinverse agonists/antagonists.
Ref 527995J Med Chem. 2006 Feb 9;49(3):872-82.Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cannabinoid receptorinverse agonists/antagonists.

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