Drug Information

Drug General Information
Drug ID
D0WU1S
Former ID
DIB020029
Drug Name
I-BET151
Synonyms
GSK1210151A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531641]
Structure
Download
2D MOL
Formula
C23H21N5O3
InChI
InChI=1S/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/m1/s1
InChIKey
VUVUVNZRUGEAHB-CYBMUJFWSA-N
PubChem Compound ID
52912189
PubChem Substance ID
123047600, 126497302, 136349820, 136946561, 137139512, 144116025, 152258476, 160647311, 160683043, 160859765, 162011757, 163393952, 163843319, 164044971, 170484596, 170484681, 174006346, 174527122, 185998846, 187051820, 189561511, 223391545, 223630419, 223705207, 224621035, 228073473, 242586692, 249730469, 249864793, 250211199, 252070128, 252445238, 252552925, 252819653
Target and Pathway
Target(s) Bromodomain-containing protein 4 Target Info Inhibitor [531641]
Bromodomain-containing protein 2 Target Info Inhibitor [531641]
Bromodomain-containing protein 3 Target Info Inhibitor [531641]
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
Pathway Interaction Database Regulation of retinoblastoma protein
WikiPathways Chemical Compounds to monitor ProteinsWP3295:Chemical Compounds to monitor ProteinsWP3295:Chemical Compounds to monitor Proteins
References
Ref 531641Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature. 2011 Oct 2;478(7370):529-33.
Ref 531641Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature. 2011 Oct 2;478(7370):529-33.

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