Drug General Information
Drug ID	D0X1RQ
Former ID	DNCL001790
Drug Name	MTR105
Drug Type	Small molecular drug
Indication	Hypotension [ICD9: 458, 796.3; ICD10:I95]		Phase 2	[522040]
Company	Meditor Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Formula	C7H19N2O4PS
Canonical SMILES	CCOP(=O)(O)OCC.CCSC(=N)N
InChI	1S/C4H11O4P.C3H8N2S/c1-3-7-9(5,6)8-4-2;1-2-6-3(4)5/h3-4H2,1-2H3,(H,5,6);2H2,1H3,(H3,4,5)
InChIKey	CSYSULGPHGCBQD-UHFFFAOYSA-N
PubChem Compound ID	210823
PubChem Substance ID	9369798, 14750091, 30415300, 50008698, 51922248, 57399610, 103818814, 113447251, 117627854, 135188196, 162815846
Target and Pathway
Target(s)	Nitric-oxide synthase, endothelial	Target Info	Inhibitor	[529438]
BioCyc Pathway	Citrulline-nitric oxide cycle
KEGG Pathway	Arginine and proline metabolism
	Metabolic pathways
	Calcium signaling pathway
	cGMP-PKG signaling pathway
	HIF-1 signaling pathway
	Sphingolipid signaling pathway
	PI3K-Akt signaling pathway
	VEGF signaling pathway
	Platelet activation
	Estrogen signaling pathway
	Oxytocin signaling pathway
NetPath Pathway	Wnt Signaling Pathway
PANTHER Pathway	Angiogenesis
	Endothelin signaling pathway
	Interleukin signaling pathway
	PI3 kinase pathway
	VEGF signaling pathway
Pathway Interaction Database	Plasma membrane estrogen receptor signaling
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	Angiopoietin receptor Tie2-mediated signaling
	Thromboxane A2 receptor signaling
	SHP2 signaling
	VEGFR1 specific signals
	Signaling events mediated by VEGFR1 and VEGFR2
	PAR1-mediated thrombin signaling events
Reactome	ROS production in response to bacteria
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	eNOS activation
	Nitric oxide stimulates guanylate cyclase
	VEGFR2 mediated vascular permeability
WikiPathways	ACE Inhibitor Pathway
	EGF/EGFR Signaling Pathway
	Myometrial Relaxation and Contraction Pathways
	JAK/STAT
	Corticotropin-releasing hormone
	AGE/RAGE pathway
	Endothelin Pathways
	Leptin signaling pathway
	Effects of Nitric Oxide
	Metabolism of nitric oxide
	Angiogenesis
References
Ref 522040	ClinicalTrials.gov (NCT00482287) Pharmacokinetics and Pharmacodynamics of MTR105 in Hypotensive Cardiac Surgery Patients. U.S. National Institutes of Health.
Ref 529438	Nitric oxide synthase inhibitor (MTR-105) during open-heart surgery. A pilot double-blind placebo-controlled study of hemodynamic effects and safety. Cardiology. 2008;111(3):181-7.

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