Drug General Information
Drug ID	D0X4AL
Former ID	DNC002852
Drug Name	1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551393]
Structure		Download 2D MOL 3D MOL
Formula	C6H8O8S
PubChem Compound ID	5289528
Target and Pathway
Target(s)	Heparin-binding growth factor 2	Target Info	Inhibitor	[551393]
KEGG Pathway	MAPK signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	PI3K-Akt signaling pathway
	Signaling pathways regulating pluripotency of stem cells
	Regulation of actin cytoskeleton
	Pathways in cancer
	Proteoglycans in cancer
	Melanoma
NetPath Pathway	IL1 Signaling Pathway
Pathway Interaction Database	Glypican 1 network
	Angiopoietin receptor Tie2-mediated signaling
	Integrins in angiogenesis
	Syndecan-4-mediated signaling events
	FGF signaling pathway
Reactome	PI3K Cascade
	PIP3 activates AKT signaling
	FGFR4 ligand binding and activation
	FGFR3c ligand binding and activation
	FGFR2c ligand binding and activation
	FGFR2b ligand binding and activation
	FGFR3 mutant receptor activation
	Activated point mutants of FGFR2
	Constitutive Signaling by Aberrant PI3K in Cancer
	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
	Syndecan interactions
	Non-integrin membrane-ECM interactions
	Phospholipase C-mediated cascade: FGFR1
	Phospholipase C-mediated cascade
	Phospholipase C-mediated cascade
	Phospholipase C-mediated cascade
	SHC-mediated cascade:FGFR1
	PI-3K cascade:FGFR1
	FRS-mediated FGFR1 signaling
	PI-3K cascade:FGFR2
	SHC-mediated cascade:FGFR2
	FRS-mediated FGFR2 signaling
	SHC-mediated cascade:FGFR3
	FRS-mediated FGFR3 signaling
	PI-3K cascade:FGFR3
	FRS-mediated FGFR4 signaling
	SHC-mediated cascade:FGFR4
	PI-3K cascade:FGFR4
	Negative regulation of FGFR1 signaling
	Negative regulation of FGFR2 signaling
	Negative regulation of FGFR3 signaling
	Negative regulation of FGFR4 signaling
	RAF/MAP kinase cascade
WikiPathways	Regulation of Actin Cytoskeleton
	Endochondral Ossification
	Differentiation Pathway
	Cardiac Hypertrophic Response
	Syndecan interactions
	Extracellular matrix organization
	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
	PIP3 activates AKT signaling
	Cardiac Progenitor Differentiation
	Integrated Pancreatic Cancer Pathway
	Neural Crest Differentiation
	miR-targeted genes in squamous cell - TarBase
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	Signaling by FGFR
	MicroRNAs in cardiomyocyte hypertrophy
	Angiogenesis
References
Ref 551393	How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393	How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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