Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0X5BD
|
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| Former ID |
DIB000558
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| Drug Name |
AVE-5997
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| Synonyms |
AVE-1734; AVE-5997; Dopamine D3 antagonists, Aventis; HMR-2554
|
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| Indication | Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] | Discontinued in Phase 1 | [1] | ||
| Company |
Aventis Pharma AG
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1(c2c(sc1)cc(C(F)(F)F)cc2)N1CCN(CC1)CCCCNC(=O)Nc1ccc(c<br />c1)C
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| Target and Pathway | |||||
| Target(s) | D(3) dopamine receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Dopaminergic synapse | |||||
| Reactome | Dopamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| Nicotine Activity on Dopaminergic Neurons | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018413) | ||||
| REF 2 | Effect of dopamine D3 antagonists on PPI in DBA/2J mice or PPI deficit induced by neonatal ventral hippocampal lesions in rats. Neuropsychopharmacology. 2006 Jul;31(7):1382-92. Epub 2005 Dec 14. | ||||
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