Drug Information

Drug General Information
Drug ID
D0X5UH
Former ID
DIB003605
Drug Name
ADOZELESIN
Synonyms
Adosar; Adozelesin < Rec INN; U-73975; (7bR,8aS)-N-[2-[(1,2,4,5,8,8a-Hexahydro-7-methyl-4-oxocyclopropa[c]pyrrolo[3,2-e]indol-2-yl)carbonyl]-1H-indol-5-yl]-2-benzofurancarboxamide
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 2 [544754]
Structure
Download
2D MOL

3D MOL
Formula
C30H22N4O4
Canonical SMILES
Cc1c[nH]c2C(=O)C=C3N(C[C@H]4C[C@@]34c12)C(=O)c5cc6cc(NC<br />(=O)c7oc8ccccc8c7)ccc6[nH]5
InChI
1S/C30H22N4O4/c1-15-13-31-27-22(35)11-25-30(26(15)27)12-18(30)14-34(25)29(37)21-9-17-8-19(6-7-20(17)33-21)32-28(36)24-10-16-4-2-3-5-23(16)38-24/h2-11,13,18,31,33H,12,14H2,1H3,(H,32,36)/t18-,30+/m1/s1
InChIKey
BYRVKDUQDLJUBX-JJCDCTGGSA-N
CAS Number
CAS 110314-48-2
PubChem Compound ID
6917987
Target and Pathway
Target(s) Human DNA Target Info Binder [533918]
References
Ref 544754Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000874)
Ref 533918Mapping of DNA alkylation sites induced by adozelesin and bizelesin in human cells by ligation-mediated polymerase chain reaction. Biochemistry. 1994 May 17;33(19):6024-30.

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