Drug Information

Drug General Information
Drug ID
D0X5UN
Former ID
DNAP001695
Drug Name
Mirabegron
Synonyms
Myrbetriq (TN)
Drug Type
Small molecular drug
Indication Overactive bladder disorder [ICD9: 188, 596.51; ICD10:C67, N32.81] Approved [532210], [542469]
Company
Astellas
Structure
Download
2D MOL

3D MOL
Formula
C21H24N4O2S
InChI
InChI=1S/C21H24N4O2S/c22-21-25-18(14-28-21)12-20(27)24-17-8-6-15(7-9-17)10-11-23-13-19(26)16-4-2-1-3-5-16/h1-9,14,19,23,26H,10-13H2,(H2,22,25)(H,24,27)/t19-/m0/s1
InChIKey
PBAPPPCECJKMCM-IBGZPJMESA-N
CAS Number
CAS 223673-61-8
PubChem Compound ID
9865528
PubChem Substance ID
14830284, 15100038, 24157536, 45287794, 80776075, 96026215, 104179241, 131305973, 135262850, 135264045, 137204503, 141480260, 152258601, 160644771, 160647435, 160708387, 164178021, 164230555, 164763064, 172914174, 175267526, 175427137, 178104017, 186007037, 187072486, 188932513, 218903013, 223541479, 223664787, 223701034, 223917501, 227170942, 242060285, 248359277, 249867219, 251963956, 251971077, 252160992, 252227885, 252448538, 252553766
ChEBI ID
ChEBI:65349
SuperDrug ATC ID
G04BD12
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Modulator [532210]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 542469(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7445).
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.

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