Drug Information

Drug General Information
Drug ID
D0X5WD
Former ID
DNC006429
Drug Name
3-isopropyl-4-(phenylamino)naphthalene-1,2-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527986]
Structure
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2D MOL

3D MOL
Formula
C19H17NO2
Canonical SMILES
CC(C)C1=C(C2=CC=CC=C2C(=O)C1=O)NC3=CC=CC=C3
InChI
1S/C19H17NO2/c1-12(2)16-17(20-13-8-4-3-5-9-13)14-10-6-7-11-15(14)18(21)19(16)22/h3-12,20H,1-2H3
InChIKey
HHIYZEJIOLXXOB-UHFFFAOYSA-N
PubChem Compound ID
44409841
Target and Pathway
Target(s) M-phase inducer phosphatase 1 Target Info Inhibitor [527986]
M-phase inducer phosphatase 2 Target Info Inhibitor [527986]
KEGG Pathway Cell cycle
Progesterone-mediated oocyte maturation
MicroRNAs in cancerhsa04010:MAPK signaling pathway
MicroRNAs in cancer
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Wnt Signaling Pathway
Pathway Interaction Database E2F transcription factor network
ATR signaling pathway
Validated targets of C-MYC transcriptional activation
ATM pathwayplk1_pathway:PLK1 signaling events
FOXM1 transcription factor network
p38 signaling mediated by MAPKAP kinases
Aurora A signaling
Reactome E2F mediated regulation of DNA replication
G0 and Early G1
Polo-like kinase mediated events
Cyclin B2 mediated events
Activation of ATR in response to replication stress
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
Cyclin A/B1 associated events during G2/M transition
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Cyclin A:Cdk2-associated events at S phase entryR-HSA-157881:Cyclin B2 mediated events
Cyclin A:Cdk2-associated events at S phase entry
WikiPathways DNA Damage Response
G1 to S cell cycle control
S Phase
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Mitotic G1-G1/S phases
Cell Cycle
Cell Cycle Checkpoints
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage ResponseWP615:Senescence and Autophagy in Cancer
MAPK Signaling Pathway
Mitotic G2-G2/M phases
References
Ref 527986Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.
Ref 527986Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.

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