Drug Information

Drug General Information
Drug ID
D0X9CU
Former ID
DIB020949
Drug Name
SK&F 83589
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543078]
Structure
Download
2D MOL
Formula
C13H11N3O4
InChI
InChI=1S/C13H11N3O4/c17-12-8-10(16(19)20)6-7-11(12)15-13(18)14-9-4-2-1-3-5-9/h1-8,17H,(H2,14,15,18)
InChIKey
SAUHQYBXEGARCC-UHFFFAOYSA-N
PubChem Compound ID
3618472
PubChem Substance ID
434896, 4927542, 9766907, 16486267, 52095760, 71825000, 103195215, 104030341, 112073416, 118221589, 129209477, 134341060, 135651056, 139810826, 143834067, 163180184, 231406844, 241162311, 241303783
Target and Pathway
Target(s) High affinity interleukin-8 receptor B Target Info Antagonist [534611]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Epithelial cell signaling in Helicobacter pylori infection
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
Pathway Interaction Database IL8- and CXCR2-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 543078(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 834).
Ref 534611Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem. 1998 Apr 24;273(17):10095-8.

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