Drug Information

Drug General Information
Drug ID
D0XA3W
Former ID
DIB016041
Drug Name
Calcium-sensing receptor antagonists
Synonyms
Calcium-sensing receptor antagonists (osteoporosis); Calcium-sensing receptor antagonists (osteoporosis), Pfizer
Indication Osteoporosis [ICD9: 733.0, V07.4; ICD10:M80-M81, Z79.890] Investigative [552136]
Company
Pfizer Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
CC(C)(NC[C@H](CO[C@@H](c1c(cccc1)c1cc(c(cc1)C(=O)O)C)C)<br />O)Cc1ccc(cc1)SC
Target and Pathway
Target(s) Extracellular calcium-sensing receptor Target Info Antagonist [543874]
Pathway Interaction Database E-cadherin signaling in keratinocytes
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 552136Metabolism-guided design of short-acting calcium-sensing receptor antagonists. ACS Med Chem Lett. 2010 May 13;1(5):219-23
Ref 543874(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 54).

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