Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0XB0T
|
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| Former ID |
DNCL002602
|
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| Drug Name |
Acolbifene
|
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| Drug Type |
Small molecular drug
|
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| Indication | Breast cancer [ICD9: 174, 175; ICD10:C50] | Phase 3 | [523658] | ||
| Company |
EndoCeutics
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C29H31NO4
|
||||
| Canonical SMILES |
CC1=C(C(OC2=C1C=CC(=C2)O)C3=CC=C(C=C3)OCCN4CCCCC4)C5=CC<br />=C(C=C5)O
|
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| InChI |
1S/C29H31NO4/c1-20-26-14-11-24(32)19-27(26)34-29(28(20)21-5-9-23(31)10-6-21)22-7-12-25(13-8-22)33-18-17-30-15-3-2-4-16-30/h5-14,19,29,31-32H,2-4,15-18H2,1H3/t29-/m0/s1
|
||||
| InChIKey |
DUYNJNWVGIWJRI-LJAQVGFWSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Estrogen receptor | Target Info | Modulator | [527443] | |
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
| Signaling events mediated by HDAC Class II | |||||
| Plasma membrane estrogen receptor signaling | |||||
| LKB1 signaling events | |||||
| Regulation of Telomerase | |||||
| ATF-2 transcription factor network | |||||
| AP-1 transcription factor network | |||||
| FOXM1 transcription factor network | |||||
| Validated nuclear estrogen receptor alpha network | |||||
| Signaling mediated by p38-alpha and p38-beta | |||||
| FOXA1 transcription factor network | |||||
| References | |||||
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