Drug General Information
Drug ID	D0XQ2T
Former ID	DNC005175
Drug Name	Drug 311440
Synonyms	311440
Indication	Discovery agent		Investigative	[527143]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Presenilin 2	Target Info	Inhibitor	[527143]
	Presenilin 1	Target Info	Inhibitor	[527143]
	Gamma-secretase	Target Info	Inhibitor	[527143]
KEGG Pathway	Notch signaling pathway
	Neurotrophin signaling pathway
	Alzheimer's diseasehsa04310:Wnt signaling pathway
	Alzheimer's diseasehsa04330:Notch signaling pathway
	Alzheimer's disease
NetPath Pathway	Notch Signaling Pathway
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Alzheimer disease-presenilin pathway
	Notch signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Notch signaling pathway
Pathway Interaction Database	LKB1 signaling eventsnotch_pathway:Notch signaling pathway
	Presenilin action in Notch and Wnt signaling
	p75(NTR)-mediated signaling
	Syndecan-3-mediated signaling eventsnotch_pathway:Notch signaling pathway
	Syndecan-3-mediated signaling events
Reactome	Nuclear signaling by ERBB4
	Regulated proteolysis of p75NTR
	NRIF signals cell death from the nucleus
	Activated NOTCH1 Transmits Signal to the Nucleus
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	NOTCH2 Activation and Transmission of Signal to the Nucleus
	EPH-ephrin mediated repulsion of cellsR-HSA-1474228:Degradation of the extracellular matrixR-HSA-1251985:Nuclear signaling by ERBB4
	EPH-ephrin mediated repulsion of cells
WikiPathways	Notch Signaling Pathway
	Signaling by ERBB4
	Signaling by NOTCH3
	Signaling by NOTCH4
	Signaling by NOTCH1
	Signaling by NOTCH2
	Notch Signaling Pathway
	Alzheimers Disease
	Signalling by NGFWP61:Notch Signaling Pathway
	Alzheimers DiseaseWP61:Notch Signaling Pathway
	Signalling by NGF
References
Ref 527143	J Med Chem. 2004 Jul 29;47(16):3931-3.Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.
Ref 527143	J Med Chem. 2004 Jul 29;47(16):3931-3.Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.

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