Drug Information

Drug General Information
Drug ID
D0XQ8A
Former ID
DIB001132
Drug Name
TPN-729
Synonyms
TPN-729B; PDE5 inhibitors (erectile dysfunction/pulmonary arterial hypertension), Shanghai Institute of Materia Medica/Topharman Shanghai
Indication Erectile dysfunction [ICD9: 302.72, 607.84; ICD10:F52.2, N48.4] Investigative [543407]
Company
Shanghai Institute of Materia Medica of the Chinese Academy of Sciences
Structure
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2D MOL

3D MOL
Canonical SMILES
c1(cc(c2c(c1Cl)nc([nH]c2=O)c1c(ccc(c1)S(=O)(=O)N1CCN(CC<br />1)C)OCC)OC)OC
Target and Pathway
Target(s) CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Inhibitor [543407]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome cGMP effects
References
Ref 543407(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1304).
Ref 543407(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1304).

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