Drug Information

Drug General Information
Drug ID
D0XT3Z
Former ID
DIB020141
Drug Name
KN-93
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541268]
Structure
Download
2D MOL
Formula
C26H29ClN2O4S
InChI
InChI=1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+
InChIKey
LLLQTDSSHZREGW-AATRIKPKSA-N
PubChem Compound ID
5312122
PubChem Substance ID
3153136, 7979427, 11056888, 14884365, 26755743, 26759024, 26759027, 39341742, 47365001, 47662090, 48259037, 49738155, 50064396, 53790031, 57359517, 77867635, 85787247, 91746510, 92310321, 99302772, 103399953, 104003964, 104051625, 114157927, 118696806, 124658740, 135073052, 135698066, 136367905, 140288316, 144116106, 152133989, 152344097, 162092708, 163620902, 163686223, 163687821, 163687824, 164761499, 172820840, 175426318, 178102624, 179148644, 180438585, 184593035, 185998765, 187071968, 204370447, 228142707, 241034292
Target and Pathway
Target(s) CaM kinase II Target Info Inhibitor [526252]
KEGG Pathway ErbB signaling pathway
Calcium signaling pathway
cAMP signaling pathway
HIF-1 signaling pathway
Oocyte meiosis
Adrenergic signaling in cardiomyocytes
Wnt signaling pathway
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Dopaminergic synapse
Olfactory transduction
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Melanogenesis
Oxytocin signaling pathway
Glucagon signaling pathway
Gastric acid secretion
Amphetamine addiction
Tuberculosis
Proteoglycans in cancer
Glioma
Reactome HSF1-dependent transactivation
Trafficking of AMPA receptors
Ca2+ pathway
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascade
Interferon gamma signaling
WikiPathways ErbB Signaling Pathway
Calcium Regulation in the Cardiac Cell
EGF/EGFR Signaling Pathway
Myometrial Relaxation and Contraction Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
Corticotropin-releasing hormone
B Cell Receptor Signaling Pathway
References
Ref 541268(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6002).
Ref 526252Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound. J Med Chem. 2002 Jan 31;45(3):563-6.

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