Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Y0AP
|
||||
| Former ID |
DIB003320
|
||||
| Drug Name |
GR-144053
|
||||
| Drug Type |
Small molecular drug
|
||||
| Company |
Glaxo Wellcome plc
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C18H27N5O2
|
||||
| InChI |
InChI=1S/C18H27N5O2/c19-18(20)14-1-3-15(4-2-14)22-9-11-23(12-10-22)16-5-7-21(8-6-16)13-17(24)25/h1-4,16H,5-13H2,(H3,19,20)(H,24,25)
|
||||
| InChIKey |
QGEGSJUSWLLZLH-UHFFFAOYSA-N
|
||||
| CAS Number |
CAS 201304-22-5
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Glycoprotein IIb/IIIa receptor | Target Info | Modulator | ||
| Reactome | Platelet degranulation | ||||
| Elastic fibre formation | |||||
| PECAM1 interactions | |||||
| Molecules associated with elastic fibres | |||||
| Integrin cell surface interactions | |||||
| Syndecan interactions | |||||
| ECM proteoglycans | |||||
| Integrin alphaIIb beta3 signaling | |||||
| GRB2:SOS provides linkage to MAPK signaling for Integrins | |||||
| p130Cas linkage to MAPK signaling for integrins | |||||
| VEGFA-VEGFR2 Pathway | |||||
| MAP2K and MAPK activation | |||||
| References | |||||
| Ref 541707 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6587). | ||||
| Ref 545648 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004027) | ||||
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