Drug Information

Drug General Information
Drug ID
D0Y4DY
Former ID
DIB013376
Drug Name
Xylometazoline
Synonyms
Xylometazoline (nasal mucoadhesive/MucoAd, congestion); Decongestant (nasal mucoadhesive/MucoAd, congestion), Strategic BioSciences; Xylometazoline (nasal mucoadhesive/MucoAd, congestion), Strategic BioSciences
Drug Type
Small molecular drug
Indication Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] Phase 4 [468231], [522245]
Company
Fortune Apex Development Ltd
Structure
Download
2D MOL

3D MOL
Formula
C16H24N2
InChI
InChI=1S/C16H24N2/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15/h8-9H,6-7,10H2,1-5H3,(H,17,18)
InChIKey
HUCJFAOMUPXHDK-UHFFFAOYSA-N
CAS Number
CAS 526-36-3
PubChem Compound ID
5709
PubChem Substance ID
10115, 6383463, 7980899, 8153498, 10525289, 11111974, 11111975, 11335333, 11360572, 11363276, 11365838, 11368400, 11371632, 11374042, 11376562, 11461544, 11466251, 11467371, 11484646, 11485922, 11488761, 11490402, 11492197, 11494196, 14823275, 29224746, 47291005, 47440118, 47515181, 47810616, 47810617, 47885277, 47959589, 48259083, 49698391, 49980614, 50100368, 50104259, 50663281, 57322906, 81115495, 85209855, 85789475, 87676529, 90340774, 96025367, 99443248, 103270012, 103936650, 104310028
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Modulator [530593], [551871]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 468231(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 517).
Ref 522245ClinicalTrials.gov (NCT00630474) Nasal Decongestion and Obstructive Sleep Apnea. U.S. National Institutes of Health.
Ref 530593Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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