Drug Information

Drug General Information
Drug ID
D0Y5AM
Former ID
DAP001131
Drug Name
Darifenacin
Synonyms
Emselex; Emselex (TN); Enablex (TN); Darifenacin (USAN/INN); (S)-1-(2-(2,3-Dihydro-5-benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide; 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide; 2-{(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide
Drug Type
Small molecular drug
Indication Overactive bladder disorder [ICD9: 188, 596.51; ICD10:C67, N32.81] Approved [527466], [536361], [540188]
Therapeutic Class
Urinary antispasmodics
Company
Norvatis Phamaceuticals Corporation
Structure
Download
2D MOL

3D MOL
Formula
C28H30N2O2
InChI
InChI=1S/C28H30N2O2/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26/h1-12,19,25H,13-18,20H2,(H2,29,31)/t25-/m1/s1
InChIKey
HXGBXQDTNZMWGS-RUZDIDTESA-N
CAS Number
CAS 133099-04-4
PubChem Compound ID
444031
PubChem Substance ID
7979027, 10944518, 14856314, 17397751, 36887144, 46508104, 50070895, 50113277, 50275204, 81145912, 85083117, 85583237, 92719451, 103435149, 104004586, 104631174, 126620787, 126651550, 128126220, 134338376, 135030473, 135650160, 135651146, 136947991, 137004287, 142807983, 144240344, 152047381, 160963842, 163621141, 163686486, 164826587, 175268333, 179149827, 186007015, 196107254, 223541474, 223831811, 226439188, 241032006, 249858507, 251916719, 251917958, 252215250
SuperDrug ATC ID
G04BD10
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M3 Target Info Antagonist [537284]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretion
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Gastric Acid Production
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 5274662004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4.
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 540188(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 321).
Ref 537284M(1) and M(3) muscarinic receptors are involved in the release of urinary bladder-derived relaxant factor. Pharmacol Res. 2009 May;59(5):300-5. Epub 2009 Feb 5.

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