| Drug General Information |
| Drug ID |
D0Y5BR
|
| Former ID |
DIB002419
|
| Drug Name |
Phylomers
|
| Synonyms |
PYC-35; PYC-35T; PYC-36D; PYC-36S; PYCAG-5; S-20; S-22; S-30; S-35; SP-34; SP-36; SP-71; Jun N terminal kinase inhibitors (stroke), Phylogica; Phylomers (traumatic brain injury/stroke); Phylomers (traumatic brain injury/stroke), Phylogica
|
| Drug Type |
Small molecular drug
|
| Indication |
Brain injury [ICD10:S09.90]
|
Investigative |
[1]
|
|---|
| Company |
Phylogica Ltd
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C23H28N2O3
|
| InChI |
InChI=1S/C23H28N2O3/c1-16(2)24-21(26)23(3)14-19(23)20(18-12-8-5-9-13-18)25-22(27)28-15-17-10-6-4-7-11-17/h4-13,16,19-20H,14-15H2,1-3H3,(H,24,26)(H,25,27)
|
| InChIKey |
ONJDWAYKGBYQHM-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
|
| Target and Pathway |
| Target(s) |
Mitogen-activated protein kinase 8 |
Target Info |
Inhibitor |
[2]
|
|---|
|
KEGG Pathway
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MAPK signaling pathway
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ErbB signaling pathway
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Ras signaling pathway
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cAMP signaling pathway
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FoxO signaling pathway
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Sphingolipid signaling pathway
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Protein processing in endoplasmic reticulum
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Wnt signaling pathway
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Osteoclast differentiation
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Focal adhesion
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Toll-like receptor signaling pathway
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NOD-like receptor signaling pathway
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RIG-I-like receptor signaling pathway
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Fc epsilon RI signaling pathway
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TNF signaling pathway
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Neurotrophin signaling pathway
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Retrograde endocannabinoid signaling
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Dopaminergic synapse
|
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Inflammatory mediator regulation of TRP channels
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Insulin signaling pathway
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GnRH signaling pathway
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Progesterone-mediated oocyte maturation
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Prolactin signaling pathway
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Adipocytokine signaling pathway
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Type II diabetes mellitus
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Non-alcoholic fatty liver disease (NAFLD)
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Epithelial cell signaling in Helicobacter pylori infection
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Shigellosis
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Salmonella infection
|
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Pertussis
|
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Chagas disease (American trypanosomiasis)
|
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Toxoplasmosis
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Tuberculosis
|
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Hepatitis C
|
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Hepatitis B
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Influenza A
|
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HTLV-I infection
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Herpes simplex infection
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Epstein-Barr virus infection
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Pathways in cancer
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Colorectal cancer
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Pancreatic cancer
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Choline metabolism in cancer
|
|
NetPath Pathway
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IL5 Signaling Pathway
|
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TNFalpha Signaling Pathway
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
|
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Angiogenesis
|
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Apoptosis signaling pathway
|
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B cell activation
|
|
FAS signaling pathway
|
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Integrin signalling pathway
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Interferon-gamma signaling pathway
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Oxidative stress response
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PDGF signaling pathway
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Parkinson disease
|
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TGF-beta signaling pathway
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T cell activation
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Toll receptor signaling pathway
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Ras Pathway
|
|
CCKR signaling map ST
|
|
Pathway Interaction Database
|
Fc-epsilon receptor I signaling in mast cells
|
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Endothelins
|
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BCR signaling pathway
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RhoA signaling pathway
|
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Noncanonical Wnt signaling pathway
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CD40/CD40L signaling
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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Osteopontin-mediated events
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Reelin signaling pathway
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TRAIL signaling pathway
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CDC42 signaling events
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Signaling events regulated by Ret tyrosine kinase
|
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Angiopoietin receptor Tie2-mediated signaling
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FAS (CD95) signaling pathway
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IL1-mediated signaling events
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Glucocorticoid receptor regulatory network
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IL2-mediated signaling events
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Rapid glucocorticoid signaling
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FoxO family signaling
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Ceramide signaling pathway
|
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Regulation of Androgen receptor activity
|
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p75(NTR)-mediated signaling
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ErbB1 downstream signaling
|
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ATF-2 transcription factor network
|
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ErbB2/ErbB3 signaling events
|
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PDGFR-beta signaling pathway
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JNK signaling in the CD4+ TCR pathway
|
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Nephrin/Neph1 signaling in the kidney podocyte
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HIV-1 Nef: Negative effector of Fas and TNF-alpha
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Retinoic acid receptors-mediated signaling
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Signaling events mediated by Stem cell factor receptor (c-Kit)
|
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EPO signaling pathway
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Syndecan-2-mediated signaling events
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Ephrin B reverse signaling
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p53 pathway
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N-cadherin signaling events
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S1P2 pathway
|
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Downstream signaling in naï
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RAC1 signaling pathway
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Signaling events mediated by focal adhesion kinase
|
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Glypican 3 network
|
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IL12 signaling mediated by STAT4
|
|
PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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Fc Epsilon Receptor I Signaling in Mast Cells
|
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Reactome
|
NRAGE signals death through JNK
|
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NRIF signals cell death from the nucleus
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Oxidative Stress Induced Senescence
|
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FCERI mediated MAPK activation
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DSCAM interactions
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JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
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Activation of the AP-1 family of transcription factors
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Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
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WikiPathways
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Toll-like receptor signaling pathway
|
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DNA Damage Response (only ATM dependent)
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TCR Signaling Pathway
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ErbB Signaling Pathway
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Insulin Signaling
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EGF/EGFR Signaling Pathway
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MAPK Signaling Pathway
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TGF beta Signaling Pathway
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FAS pathway and Stress induction of HSP regulation
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Signaling of Hepatocyte Growth Factor Receptor
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Kit receptor signaling pathway
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Transcriptional activation by NRF2
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NLR Proteins
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IL-3 Signaling Pathway
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Cardiac Hypertrophic Response
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Nanoparticle-mediated activation of receptor signaling
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Structural Pathway of Interleukin 1 (IL-1)
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EBV LMP1 signaling
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JAK/STAT
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PDGF Pathway
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Nanoparticle triggered regulated necrosis
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BDNF signaling pathway
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Integrated Pancreatic Cancer Pathway
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Oncostatin M Signaling Pathway
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Corticotropin-releasing hormone
|
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AGE/RAGE pathway
|
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TNF alpha Signaling Pathway
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B Cell Receptor Signaling Pathway
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Prostate Cancer
|
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TSLP Signaling Pathway
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TWEAK Signaling Pathway
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Leptin signaling pathway
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RANKL/RANK Signaling Pathway
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Signalling by NGF
|
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IL-1 signaling pathway
|
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Intrinsic Pathway for Apoptosis
|
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DSCAM interactions
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Apoptosis Modulation and Signaling
|
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Type II diabetes mellitus
|
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MicroRNAs in cardiomyocyte hypertrophy
|
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Physiological and Pathological Hypertrophy of the Heart
|
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Regulation of toll-like receptor signaling pathway
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Osteoclast Signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2773). |
|---|
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1496). |
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