Drug Information

Drug General Information
Drug ID
D0Y6HV
Former ID
DIB005317
Drug Name
EMD-53998
Synonyms
5-[1-(3,4-Dimethoxybenzoyl)-1,2,3,4-tetrahydroquinolin-6-yl]-6-methyl-3,6-dihydro-2H-1,3,4-thiadiazin-2-one
Drug Type
Small molecular drug
Indication Cardiovascular disorder [ICD10:I00-I99] Discontinued in Phase 1 [544631]
Structure
Download
2D MOL

3D MOL
Formula
C22H23N3O4S
Canonical SMILES
COc1ccc(cc1OC)C(=O)N2CCCc3cc(ccc23)C4=NNC(=O)SC4C
InChI
1S/C22H23N3O4S/c1-13-20(23-24-22(27)30-13)15-6-8-17-14(11-15)5-4-10-25(17)21(26)16-7-9-18(28-2)19(12-16)29-3/h6-9,11-13H,4-5,10H2,1-3H3,(H,24,27)
InChIKey
IZLRMTJLQCLMKF-UHFFFAOYSA-N
CAS Number
CAS 120223-04-3
PubChem Compound ID
187079
Target and Pathway
Target(s) CGMP-inhibited 3',5'-cyclic phosphodiesterase A Target Info Inhibitor [551871]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
cAMP signaling pathway
Morphine addiction
Reactome cGMP effects
G alpha (s) signalling events
WikiPathways miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 544631Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000367)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.