Drug Information

Drug General Information
Drug ID
D0Y6TI
Former ID
DPR000121
Drug Name
YM-355179
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Preclinical [536958], [542846]
Company
Astellas
Structure
Download
2D MOL

3D MOL
Formula
C29H31FN4O3
InChI
InChI=1S/C29H31FN4O3/c1-19-12-26(35)28(31-16-19)29(37)34-10-6-20(7-11-34)14-27(36)32-25-8-9-33(18-25)17-21-2-3-23-15-24(30)5-4-22(23)13-21/h2-5,12-16,25,35H,6-11,17-18H2,1H3,(H,32,36)/t25-/m1/s1
InChIKey
LHTPHICFHRATTG-RUZDIDTESA-N
PubChem Compound ID
11556309
PubChem Substance ID
42698205, 75808985, 135651345, 229792078, 248980079
Target and Pathway
Target(s) C-C chemokine receptor type 3 Target Info Antagonist [536958]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Viral carcinogenesis
NetPath Pathway IL3 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
IL1 and megakaryotyces in obesity
IL-3 Signaling Pathway
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 536958Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53.
Ref 542846(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 793).
Ref 536958Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53.

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