Drug General Information
Drug ID	D0Y6UB
Former ID	DNC000053
Drug Name	2-PMPA
Drug Type	Small molecular drug
Indication	Discovery agent		Terminated	[546702]
Structure		Download 2D MOL 3D MOL
Formula	C6H11O7P
Canonical SMILES	C(CC(=O)O)C(CP(=O)(O)O)C(=O)O
InChI	1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)
InChIKey	ISEYJGQFXSTPMQ-UHFFFAOYSA-N
CAS Number	CAS 380603-10-1
PubChem Compound ID	10130754
PubChem Substance ID	15121544, 22533549, 39969184, 46517820, 50002643, 50112859, 57374253, 77250760, 103230319, 125640593, 128212870, 134224448, 134339598, 134340806, 137010259, 142391146, 160830077, 162022820, 162448650, 163394392, 163843169, 172873791, 180677325, 184538750, 186020734, 189614600, 204418430, 226713916, 241182379, 242069708, 249841889, 250182203, 250212573, 252045761, 252212931, 252328680, 252433515, 252560384
Target and Pathway
Target(s)	Glutamate carboxypeptidase II	Target Info	Inhibitor	[534932]
KEGG Pathway	Alanine, aspartate and glutamate metabolism
	Metabolic pathways
	Vitamin digestion and absorption
NetPath Pathway	TCR Signaling Pathway
	TNFalpha Signaling Pathway
Reactome	Amino acid synthesis and interconversion (transamination)
WikiPathways	One Carbon Metabolism
References
Ref 546702	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009714)
Ref 534932	Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat Med. 1999 Dec;5(12):1396-402.

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