Drug General Information
Drug ID	D0Y7CS
Former ID	DNC010479
Drug Name	2-(tert-butylamino)-1-m-tolylpropan-1-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530728]
Structure		Download 2D MOL 3D MOL
Formula	C14H21NO
Canonical SMILES	CC1=CC=CC(=C1)C(=O)C(C)NC(C)(C)C
InChI	1S/C14H21NO/c1-10-7-6-8-12(9-10)13(16)11(2)15-14(3,4)5/h6-9,11,15H,1-5H3
InChIKey	YDGOUEKZXBLUDG-UHFFFAOYSA-N
PubChem Compound ID	44543118
Target and Pathway
Target(s)	Sodium-dependent noradrenaline transporter	Target Info	Inhibitor	[530728]
	Sodium-dependent dopamine transporter	Target Info	Inhibitor	[530728]
KEGG Pathway	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Amphetamine addiction
	Alcoholism
PANTHER Pathway	Adrenaline and noradrenaline biosynthesisP00001:Adrenaline and noradrenaline biosynthesis
	Parkinson disease
	Dopamine receptor mediated signaling pathway
Pathway Interaction Database	Alpha-synuclein signaling
Reactome	Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways	Monoamine Transport
	NRF2 pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
	Dopaminergic Neurogenesis
	Parkinsons Disease Pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 530728	J Med Chem. 2010 Mar 11;53(5):2204-14.Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation.
Ref 530728	J Med Chem. 2010 Mar 11;53(5):2204-14.Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation.

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