Drug Information

Drug General Information
Drug ID
D0Y7NA
Former ID
DCL000300
Drug Name
INCB9471
Drug Type
Small molecular drug
Indication Infections [ICD9: 001-139; ICD10:A00-B99] Phase 2a [548244]
Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Phase 2 [549860]
Company
Incyte
Structure
Download
2D MOL

3D MOL
Formula
C30H40F3N5O2
Canonical SMILES
CCOC1CC2=C(C1N3CCN(CC3C)C4(CCN(CC4)C(=O)C5=C(N=CN=C5C)C<br />)C)C=CC(=C2)C(F)(F)F
InChI
1S/C30H40F3N5O2/c1-6-40-25-16-22-15-23(30(31,32)33)7-8-24(22)27(25)38-14-13-37(17-19(38)2)29(5)9-11-36(12-10-29)28(39)26-20(3)34-18-35-21(26)4/h7-8,15,18-19,25,27H,6,9-14,16-17H2,1-5H3/t19-,25+,27+/m0/s1
InChIKey
ZMCJFJZOSKEMOM-DNKZPPIMSA-N
PubChem Compound ID
49871007
PubChem Substance ID
124970458, 125089135, 134338956, 135338106, 140576286, 163642784, 198965190, 229672092, 246652140
Target and Pathway
Target(s) C-C chemokinereceptor type 5 Target Info Antagonist [536516]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Toxoplasmosis
Viral carcinogenesis
NetPath Pathway TSLP Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database IL12-mediated signaling events
Reactome Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
HIV Life Cycle
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 548244Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023697)
Ref 549860Clinical pipeline report, company report or official report of Incyte.
Ref 536516Species selectivity of small-molecular antagonists for the CCR5 chemokine receptor. Int Immunopharmacol. 2007 Dec 5;7(12):1528-34. Epub 2007 Aug 14.

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