Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Y7PG
|
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| Former ID |
DAP000607
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| Drug Name |
Tolcapone
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| Synonyms |
Tasmar; Roche brand of tolcapone; Ro 40-7592; Tasmar (TN); Tolcapone [USAN:INN]; Ro-40-7592; Tolcapone (JAN/USAN/INN); Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl); (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone; (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone; 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone; 3,4-dihydroxy-5'-methyl-5-nitrobenzophenone
|
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| Drug Type |
Small molecular drug
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| Indication | Parkinson's disease [ICD9: 332; ICD10:G20] | Approved | [1], [2] | ||
| Therapeutic Class |
Antiparkinson Agents
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| Structure |
|
Download2D MOL |
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| Formula |
C14H11NO5
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| InChI |
InChI=1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7,16,18H,1H3
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| InChIKey |
MIQPIUSUKVNLNT-UHFFFAOYSA-N
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| CAS Number |
CAS 134308-13-7
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| PubChem Compound ID | |||||
| PubChem Substance ID |
10150, 591969, 6867176, 7847851, 7979465, 9606603, 11528675, 12014507, 15221967, 36965801, 46504932, 48416644, 50126317, 53789624, 57357233, 57394327, 77396301, 92308890, 92719235, 93166190, 99452900, 103412696, 104004042, 113211425, 118048594, 124893730, 125728425, 126573748, 126620976, 126653872, 126666929, 126732537, 128601362, 134220789, 134337898, 135029479, 135610139, 137001454, 138121037, 138139359, 144206516, 144212731, 152041747, 160963671, 162110971, 162176782, 163122304, 163621082, 163686405, 164178033
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| SuperDrug ATC ID |
N04BX01
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| SuperDrug CAS ID |
cas=134308137
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| Target and Pathway | |||||
| Target(s) | Catechol-O-methyl-transferase | Target Info | Inhibitor | [3], [4] | |
| BioCyc Pathway | L-dopa degradation | ||||
| Dopamine degradation | |||||
| Noradrenaline and adrenaline degradation | |||||
| KEGG Pathway | Steroid hormone biosynthesis | ||||
| Tyrosine metabolism | |||||
| Metabolic pathways | |||||
| Dopaminergic synapse | |||||
| PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
| Dopamine receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Tyrosine Metabolism | ||||
| WikiPathways | Methylation Pathways | ||||
| Metapathway biotransformation | |||||
| Estrogen metabolism | |||||
| Biogenic Amine Synthesis | |||||
| Dopamine metabolism | |||||
| Phase II conjugation | |||||
| Neurotransmitter Clearance In The Synaptic Cleft | |||||
| References | |||||
| REF 1 | Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6646). | ||||
| REF 3 | Tolcapone: a novel approach to Parkinson's disease. Am J Health Syst Pharm. 1999 Nov 1;56(21):2195-205. | ||||
| REF 4 | Catechol-O-methyltransferase inhibitors in the management of Parkinson's disease. Semin Neurol. 2001;21(1):15-22. | ||||
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