Drug Information

Drug General Information
Drug ID
D0Y7WL
Former ID
DNC000889
Drug Name
Lorglumide
Drug Type
Small molecular drug
Indication Pancreatic disease [ICD10:K85-K86] Terminated [543283], [544685]
Structure
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2D MOL

3D MOL
Formula
C22H32Cl2N2O4
InChI
InChI=1S/C22H32Cl2N2O4/c1-3-5-7-13-26(14-8-6-4-2)22(30)19(11-12-20(27)28)25-21(29)16-9-10-17(23)18(24)15-16/h9-10,15,19H,3-8,11-14H2,1-2H3,(H,25,29)(H,27,28)
InChIKey
IEKOTSCYBBDIJC-UHFFFAOYSA-N
CAS Number
CAS 97964-56-2
PubChem Compound ID
3960
PubChem Substance ID
7979802, 8152486, 11364522, 11367084, 11369646, 11377808, 11466943, 11468063, 11486715, 11495442, 12013646, 14858075, 29223074, 47291331, 47291332, 47589196, 47959979, 48110682, 48334727, 48334728, 50002818, 50143136, 57322069, 85209144, 85787321, 92309296, 103190039, 103839677, 103856371, 103921383, 104305024, 117462169, 128156102, 134340189, 135025885, 135650531, 137142843, 176484400, 179039128, 184548356, 226514992, 241169171
Target and Pathway
Target(s) Cholecystokinin receptor type A Target Info Antagonist [538145]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretion
Pancreatic secretion
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543283(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 891).
Ref 544685Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000580)
Ref 538145Behavioral and neurochemical study on the role of the brain cholecystokinin system in anxiety. Hokkaido Igaku Zasshi. 1998 Sep;73(5):463-73.

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