Drug Information

Drug General Information
Drug ID
D0Y7ZU
Former ID
DAP000533
Drug Name
Dacarbazine
Synonyms
Biocarbazin; Biocarbazine; DTIC; DTICDome; DTIE; Dacarbazino; Dacarbazinum; Dacatic; Decarbazine; Deticene; Dimethyltriazenoimidazolecarboxamide; ICDMT; ICDT; Biocarbazine R; DTIC Dome; Dimethyl Imidazole Carboxamide; Dimethyl Triazeno Imidazole Carboxamide; Imidazole carboxamide; HE1150000; Carboxamide (TN); Carboxamide, Dimethyl Imidazole; DIC (TN); DTIC (TN); DTIC-Dome; Dacarbazino [INN-Spanish]; Dacarbazinum [INN-Latin]; Imidazole (TN); Imidazole Carboxamide, Dimethyl; NPFAPI-05; DTIC-Dome (TN); Di-me-triazenoimidazolecarboxamide; Di-methyl-triazenoimidazolecarboxamide; Dtic-Dome (TN); DTIC, DTIC-Dome, Dacarbazine; Dacarbazine (JAN/USP/INN); Dacarbazine [USAN:INN:BAN:JAN]; (5E)-5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide; (5Z)-5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide; (Dimethyltriazeno)imidazolecarboxamide; 4(5)-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide; 4(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide; 4-(3,3-Dimethyl-1-triazeno)imidazole-5-carboxamide; 4-(3,3-Dimethyltriazeno)imidazole-5-carboxamide; 4-(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide; 4-(Dimethyltriazeno)imidazole-5-c arboxamide; 4-(Dimethyltriazeno)imidazole-5-carboxamide; 4-(or 5)-(3,3-Dimethyl-1-triazeno)imidazole-5(or 4)-carboxamide; 4-[(1E)-3,3-Dimethyltriaz-1-en-1-yl]-1H-imidazole-5-carboxamide; 4-[3,3-dimethyltriaz-1-en-1-yl]-1H-imidazole-5-carboxamide; 5(or 4)-(dimethyltriazeno)imidazol e-4(or 5)-carboxamide; 5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide; 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide; 5-(3,3-Dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide; 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide; 5-(3,3-Dimethyltri azeno)imidazole-4-carboxamide; 5-(3,3-Dimethyltriazeno)-imidazole-4-carbamide; 5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide; 5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide; 5-(Dimethyltriazeno)-4-imidazolecarboxamide; 5-(Dimethyltriazeno)imidazole-4-carboxamide; 5-(Dimethyltriazeno)imidazole-4-carboximide; 5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide; 5-[3,3-Dimethyl-1-triazenyl]imidazole-4-carboxamide
Drug Type
Small molecular drug
Indication Melanoma [ICD9: 172; ICD10:C43] Approved [538295]
Therapeutic Class
Anticancer Agents
Company
Bayer Pharmaceuticals Corporation
Structure
Download
2D MOL

3D MOL
Formula
C6H10N6O
Canonical SMILES
CN(C)NN=C1C(=NC=N1)C(=O)N
InChI
1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3,11H,1-2H3,(H2,7,13)/b10-6+
InChIKey
OMJKFYKNWZZKTK-UXBLZVDNSA-N
CAS Number
CAS 4342-03-4
PubChem Compound ID
5353562
PubChem Substance ID
9152, 7847354, 7978483, 10321843, 15147351, 24893683, 39379666, 42680836, 49698562, 49854343, 50263006, 53786765, 57361557, 85789482, 87560054, 92125354, 92309016, 103914325, 113909374, 118816621, 121363025, 121559958, 124455296, 131314849, 134337825, 134985384, 135286428, 135341553, 140170342, 140349396, 143832162, 160964192, 162177330, 164196541, 165298539, 175265531, 175611919, 176484330, 176484580, 176484944, 187072676, 210279185, 210281508, 227267566, 241085945, 251885216, 252401443
ChEBI ID
ChEBI:4305
SuperDrug ATC ID
L01AX04
SuperDrug CAS ID
cas=004342034
Target and Pathway
Target(s) DNA Target Info Breaker [537543]
References
Ref 538295FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 075259.
Ref 537543Predicting the myelotoxicity of chemotherapy: the use of pretreatment O6-methylguanine-DNA methyltransferase determination in peripheral blood mononuclear cells. Melanoma Res. 2009 Jun 25.

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