Drug Information

Drug General Information
Drug ID
D0Y8LD
Former ID
DIB018892
Drug Name
AS94
Synonyms
AS 94; AS-94
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467712]
Structure
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2D MOL

3D MOL
Formula
C26H31N7O6
InChI
InChI=1S/C26H31N7O6/c1-5-12-32-23-21(24(35)33(13-6-2)26(32)37)28-22(29-23)18-14-20(30-31(18)4)39-15-19(34)27-17-10-8-16(9-11-17)25(36)38-7-3/h8-11,14,30H,5-7,12-13,15H2,1-4H3,(H,27,34)/b22-18-
InChIKey
ZGYHEWXZOUTFGG-PYCFMQQDSA-N
PubChem Compound ID
10196356
PubChem Substance ID
15192713, 40285916, 80209039, 103207138, 104030469, 135649963, 139629069
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Antagonist [527796]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 467712(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 440).
Ref 527796Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. Biochem Pharmacol. 2005 Nov 25;70(11):1601-12. Epub 2005 Oct 10.

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