Drug General Information
Drug ID
D0Y8OK
Former ID
DAP001278
Drug Name
Peginterferon alfa-2a
Synonyms
Pegasys; Pegasys (TN); Peginterferon alfa-2a (genetical recombination); Peginterferon alfa-2a (USAN/INN); Peginterferon alfa-2a (genetical recombination) (JAN)
Indication Hairy cell leukemia [ICD9: 202.4; ICD10:C91.4] Approved [536361]
Therapeutic Class
Anticancer Agents
Company
Hoffmann-La Roche pharmaceutical company
CAS Number
CAS 198153-51-4
PubChem Substance ID
SuperDrug ATC ID
L03AB11
Target and Pathway
Target(s) Interferon alpha 2 ligand Target Info Modulator [556264]
KEGG Pathway Cytokine-cytokine receptor interaction
Regulation of autophagy
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
Tuberculosis
Hepatitis C
Hepatitis B
Measles
Influenza A
Herpes simplex infection
Autoimmune thyroid disease
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Downstream signaling in na&#xef
Reactome Interferon alpha/beta signaling
Regulation of IFNA signaling
TRAF6 mediated IRF7 activation
Factors involved in megakaryocyte development and platelet production
WikiPathways Toll-like receptor signaling pathway
Type II interferon signaling (IFNG)
Interferon alpha/beta signaling
Regulation of toll-like receptor signaling pathway
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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