Drug Information

Drug General Information
Drug ID
D0Y8UB
Former ID
DCL000335
Drug Name
Agomelatine
Synonyms
Thymanax; Valdoxan; Agomelatine [INN]; AGO 178; AGO178; S 20098; S20098; AGO-178; Agomelatine(INN); S-20098; Valdoxan (TN); Valdoxan, Melitor, Thymanax, Agomelatine; N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide; N-(2-(7-Methoxy-1-naphthalenyl)ethyl)acetamide; N-(2-(7-Methoxynaphth-1-yl)ethyl)acetamide; N-(2-(7-methoxy-1-naphthyl)ethyl)acetamide
Drug Type
Small molecular drug
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Withdrawn from market [536580], [539276]
Company
Servier
Structure
Download
2D MOL

3D MOL
Formula
C15H17NO2
InChI
InChI=1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/h3-7,10H,8-9H2,1-2H3,(H,16,17)
InChIKey
YJYPHIXNFHFHND-UHFFFAOYSA-N
CAS Number
CAS 138112-76-2
PubChem Compound ID
82148
PubChem Substance ID
7980554, 10219207, 12014766, 15121987, 17396749, 43137308, 47805575, 48029689, 48253997, 48329090, 49859801, 50597493, 53789947, 57333351, 58107135, 85175740, 85209276, 92720043, 99437046, 103171284, 103943227, 104379867, 109692881, 123121579, 124757110, 125163914, 125333716, 126620366, 126648120, 126667094, 126728359, 129806556, 131480735, 134338989, 135037533, 135588690, 135649906, 136340261, 136367368, 136368118, 136991142, 137228670, 137232583, 142374863, 144115558, 144160950, 152225873, 152258747, 152344557, 160647592
SuperDrug ATC ID
N06AX22
Target and Pathway
Target(s) Melatonin receptor Target Info Agonist [536794]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.
Ref 539276(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 198).
Ref 536794Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders. Curr Top Med Chem. 2008;8(11):954-68.

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