Drug Information

Drug General Information
Drug ID
D0Y8YE
Former ID
DIB001110
Drug Name
Lysine-specific demethylase 1 inhibitors
Synonyms
Lysine-specific demethylase 1 inhibitors (cancer); Lysine-specific demethylase 1 inhibitors (cancer), Wayne State University
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [552071]
Company
Wayne State University
Structure
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2D MOL

3D MOL
Canonical SMILES
CN/C(=N\C)/NCCCNCCCNCCCN/C(=N/C)/NC
Target and Pathway
Target(s) Lysine specific histone demethylase 1 Target Info Inhibitor [543682]
Pathway Interaction Database Notch signaling pathway
Coregulation of Androgen receptor activity
Notch-mediated HES/HEY network
Reactome HDACs deacetylate histones
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Factors involved in megakaryocyte development and platelet production
WikiPathways Factors involved in megakaryocyte development and platelet production
Androgen receptor signaling pathway
References
Ref 552071(Bis)urea and (bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators. J Med Chem. 2010 Jul 22;53(14):5197-212
Ref 543682(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2669).

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