Drug General Information
Drug ID	D0Y9GK
Former ID	DNC007168
Drug Name	4-(4-aminophenyl)-1H-indazol-3yl-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528716]
Structure		Download 2D MOL 3D MOL
Formula	C13H12N4
Canonical SMILES	C1=CC(=C2C(=C1)NN=C2N)C3=CC=C(C=C3)N
InChI	1S/C13H12N4/c14-9-6-4-8(5-7-9)10-2-1-3-11-12(10)13(15)17-16-11/h1-7H,14H2,(H3,15,16,17)
InChIKey	KHQLSBOHZQJRPC-UHFFFAOYSA-N
PubChem Compound ID	16125106
Target and Pathway
Target(s)	FL cytokine receptor	Target Info	Inhibitor	[528716]
	Mast/stem cell growth factor receptor	Target Info	Inhibitor	[528716]
	Vascular endothelial growth factor receptor 2	Target Info	Inhibitor	[528716]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Hematopoietic cell lineage
	Pathways in cancer
	Transcriptional misregulation in cancer
	Acute myeloid leukemia
	Central carbon metabolism in cancerhsa04014:Ras signaling pathway
	Rap1 signaling pathway
	Endocytosis
	PI3K-Akt signaling pathway
	Melanogenesis
	VEGF signaling pathway
	Focal adhesion
	Proteoglycans in cancer
NetPath Pathway	IL3 Signaling Pathway
	IL4 Signaling Pathway
	KitReceptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway	Angiogenesis
	VEGF signaling pathway
Pathway Interaction Database	C-MYB transcription factor network
	Signaling events mediated by Stem cell factor receptor (c-Kit)hif2pathway:HIF-2-alpha transcription factor network
	Beta3 integrin cell surface interactions
	Signaling events mediated by TCPTP
	SHP2 signaling
	S1P1 pathway
	VEGF and VEGFR signaling network
	Integrins in angiogenesis
	Signaling events mediated by VEGFR1 and VEGFR2
	Notch-mediated HES/HEY network
Reactome	PIP3 activates AKT signaling
	Regulation of KIT signaling
	Constitutive Signaling by Aberrant PI3K in Cancer
	RAF/MAP kinase cascadeR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
	VEGF binds to VEGFR leading to receptor dimerization
	Integrin cell surface interactions
	EPHA-mediated growth cone collapse
	VEGFA-VEGFR2 Pathway
	VEGFR2 mediated cell proliferation
WikiPathways	Kit receptor signaling pathway
	Differentiation Pathway
	Signaling by SCF-KIT
	PIP3 activates AKT signaling
	Cardiac Progenitor Differentiation
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBaseWP306:Focal Adhesion
	Nifedipine Activity
	Signaling by VEGF
	Angiogenesis
References
Ref 528716	J Med Chem. 2007 Apr 5;50(7):1584-97. Epub 2007 Mar 8.Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.
Ref 528716	J Med Chem. 2007 Apr 5;50(7):1584-97. Epub 2007 Mar 8.Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.

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